S5049
Sigma
Monoclonal Anti-S100A6 antibody produced in mouse
clone CACY-100, ascites fluid
| Synonym: | Anti-Calcyclin |
| MDL number: | MFCD00677384 |
Description
| Immunogen | Ca2+-binding proteins from pig stomach tissue |
| Specificity | Recognizes an epitope located on S100A6 (Calcyclin in the old terminology) in a Ca2+ ion-dependent manner. The product does not react with other members of the EF-hand family such as calmodulin, parvalbumin, intestinal calcium-binding protein, S100A2 (S100L), caltropin, the α chain of S-100 (i.e. in S-100a and S-100ao), or the β chain (i.e. in S-100a and S-100b). |
Properties
| antibody form | ascites fluid |
| clone | CACY-100 (monoclonal) |
| contains | 15 mM sodium azide |
| species reactivity | lizard, pig, canine, human, rat, bovine, goat |
| application(s) | immunoblotting: suitable using denatured-reduced preparations |
| immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable | |
| immunohistochemistry (frozen sections): suitable | |
| immunoprecipitation: suitable using native preparations | |
| indirect immunofluorescence: 1:4,000 using bovine tongue frozen sections | |
| isotype | IgG1 |
| Gene Information | human ... S100A6(6277) |
| rat ... S100a6(85247) | |
| shipped in | dry ice |
| storage temp. | −20°C |
Safety
| WGK Germany | NWG |
References
| reference | Gimona, M., et al. J. Cell Sci. 110, 611, (1997) Abstract |
| Mangin, C., et al., S100A6 and S100A11 are specific targets of the calcium- and zinc-binding S100B protein in vivo. J. Biol. Chem. 275, 35302-35310, (2000) Abstract | |
| Leniak, W., et al., S100A6 binds p53 and affects its activity. Int. J. Biochem. Cell Biol. 35, 6924-6934, (2008) | |
| Bonfrer, J., et al., Immunophenotypic markers to differentiate between benign and malignant melanocytic lesions. Br. J. Ophthalmol. 90, 213-217, (2006) Abstract |
